Non-small cell lung cancer

The PBS subsidises crizotinib and entrectinib for patients with Stage IIIB (locally advanced) or Stage IV (metastatic) non-small cell lung cancer (NSCLC).

Please note: You’ll get an immediate assessment when you request PBS authorities online.

Patient eligibility

The Pharmaceutical Benefits Scheme (PBS) subsidises treatment with crizotinib and entrectinib under the National Health Act 1953, section 85 for patients with Stage IIIB or Stage IV NSCLC.

Patients must be eligible for the PBS and meet the relevant restriction criteria.

The Schedule of Pharmaceutical Benefits on the PBS website outlines the restrictions for prescribing crizotinib and entrectinib.

Treatment specifics

Crizotinib

To be eligible for initial PBS-subsidised treatment with crizotinib, patients must be treated by a medical practitioner.

To be eligible for continuing PBS-subsidised treatment with crizotinib, patients must be treated by either a:

  • medical practitioner
  • nurse practitioner where patient care is being shared with a medical practitioner and the prescription continues existing therapy with this medicine.

Entrectinib

To be eligible for PBS-subsidised treatment with entrectinib, patients must be treated by a medical practitioner.

Authority applications

Applying for initial treatment

Applications for initial authority approval to prescribe PBS-subsidised crizotinib or entrectinib to treat Stage IIIB or Stage IV NSCLC can be made either in:

All written applications must include:

Applying for continuing treatment

Applications for continuing authority approval to prescribe PBS-subsidised crizotinib or entrectinib to treat Stage IIIB or Stage IV NSCLC can be made either:

More information

Call the PBS Complex Drugs Programs enquiry line for more information.

Page last updated: 1 February 2026.
QC 32411